HEITZ Valérie

Switchable catalysis based on 3D architectures


Stimulus-responsive control of chemical catalysis by multicomponent molecular systems, able to switch on and off the catalyst, or to switch products distribution, is highly desirable for better regulation of a wide variety of chemical reactions. Such a property of smart molecular systems is reminiscent of allosteric modulation of catalysis in some natural enzymes. Three-dimensional structures developed since the end of the 60s have shown their ability to selectively recognition guest molecules and more recently, to act as real nanoreactors.

Nevertheless, controlling thanks to an external stimulus, the release of a guest from a molecular container or the product formed within a nanoreactor, has not received much attention yet despite the promising applications for drug-delivery and catalysis. The project concerns the elaboration of dynamic prophyrinic cages incorporating peripheral regulation sites to trigger, under the action of an external stimulus, a reversible and large modulation of their sizes, in order to perform switchable catalysis.